Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.39 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15718690 | 0.87 | BTK (0.48) | GRM5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15718487 | 0.83 | TRPV1 (0.47) | GRM5MCHR1PSEN1PSEN2APH1B | |
| SCHEMBL15739740 | 0.82 | GRM5 (0.41) | GRM5MCHR1PSEN1PSEN2APH1B | |
| SCHEMBL15718631 | 0.82 | RAB9A (0.50) | GRM5MCHR1TRPV1MEN1KMT2A | |
| SCHEMBL15718206 | 0.81 | TRPV1 (0.46) | GRM5MCHR1PSEN1PSEN2APH1B | |
| SCHEMBL15739861 | 0.78 | AKT1 (0.51) | MCHR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15718945 | 0.77 | RAB9A (0.42) | GRM5MCHR1TRPV1MEN1KMT2A | |
| SCHEMBL15717978 | 0.73 | MKNK1 (0.48) | GRM5GAATRPV1DEGS1MEN1 | |
| SCHEMBL15718329 | 0.72 | CSNK1D (0.47) | GRM5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15718432 | 0.71 | KDR (0.42) | GRM5MCHR1TRPV1CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920177-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | Novartis AG (CH) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014078813-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | IRM LLC (BM) | 2014-05-22 | — | — | WO | disclosed |