Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15719981 | 0.89 | CRBN (0.33) | CRBN | |
| SCHEMBL14749800 | 0.77 | OR51E2 (0.38) | OR51E2CRBNFKBP5 | |
| SCHEMBL10730399 | 0.77 | OR51E2 (0.38) | OR51E2CRBNFKBP5 | |
| SCHEMBL14275853 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL5784604 | 0.72 | OR51E2 (0.41) | OR51E2CRBNFKBP5 | |
| Hydrochloric Acid SCHEMBL3933982 | 0.72 | OR51E2 (0.41) | OR51E2CRBNFKBP5 | |
| SCHEMBL5200385 | 0.67 | EPHX1 (0.41) | — | |
| SCHEMBL12960418 | 0.67 | — | — | |
| SCHEMBL31259486 | 0.67 | CRBN (0.43) | OR51E2CRBNFKBP5 | |
| SCHEMBL2082391 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920172-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | Merck Sharp & Dohme Corp. (US) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014075393-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP & DOHME CORP. (US) | 2014-05-22 | — | — | WO | disclosed |