Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.34 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16221723 | 0.83 | HTT (0.40) | HTTHSD17B10NOS3NOS2NCF1 | |
| SCHEMBL16992858 | 0.80 | HTT (0.49) | HTTHSD17B10NOS3NOS2NCF1 | |
| SCHEMBL21598467 | 0.78 | HTT (0.47) | HTTHSD17B10NOS3NOS2NCF1 | |
| SCHEMBL29023076 | 0.78 | HTT (0.47) | HTTHSD17B10NOS3NOS2NCF1 | |
| SCHEMBL21598605 | 0.78 | HTT (0.40) | HTTHSD17B10NOS3NOS2NR4A2 | |
| SCHEMBL30050747 | 0.78 | HTT (0.47) | HTTHSD17B10NOS3NOS2NCF1 | |
| Hydrochloric Acid SCHEMBL16992973 | 0.78 | HTT (0.47) | HTTHSD17B10NOS3NOS2NCF1 | |
| SCHEMBL22260115 | 0.74 | HTT (0.37) | HTTHSD17B10NOS3NOS2LOXL2 | |
| SCHEMBL31145846 | 0.74 | HTT (0.47) | HTTHSD17B10NOS3NOS2LOXL2 | |
| SCHEMBL16856989 | 0.74 | HTT (0.47) | HTTHSD17B10NOS3NOS2LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2436672-B1 | ANTI-SHOCK AGENT COMPRISING DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVE | ISHIHARA SANGYO KAISHA (JP) | 2017-04-12 | — | — | EP | claimed |
| US-8604212-B2 | Anti-shock agent comprising diaminotrifluoromethylpyridine derivative | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2013-12-10 | — | — | US | claimed |
| US-20120059039-A1 | ANTI-SHOCK AGENT COMPRISING DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVE | ISHIHARA SANGYO KAISHA LTD (JP) | 2012-03-08 | — | — | US | claimed |
| EP-1252890-B1 | REMEDIES OR PREVENTIVES FOR DIGESTIVE DISEASES CONTAINING DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVES | ISHIHARA SANGYO KAISHA (JP) | 2008-07-02 | — | — | EP | claimed |
| EP-1252889-B1 | REMEDIES OR PREVENTIVES FOR PULMONARY INSUFFICIENCY CONTAINING DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVES | ISHIHARA SANGYO KAISHA (JP) | 2006-08-09 | — | — | EP | claimed |
| EP-1252891-B1 | Use of DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVES FOR the prevention and treatment of LIVER DISEASES | ISHIHARA SANGYO KAISHA (JP) | 2005-10-05 | — | — | EP | claimed |
| EP-0971711-B1 | ANTICANCER COMPOSITION COMPRISING A DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVE | ISHIHARA SANGYO KAISHA (JP) | 2004-12-29 | — | — | EP | claimed |
| US-6664279-B2 | Cirrhosis | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2003-12-16 | — | — | US | claimed |
| US-6653333-B2 | Especially N-(2-ethylsulfonylamino-5-trifluoromethyl-3-pyridyl)cyclohexane; treating inflammatory bowel diseases, gastritis and peptic ulcer. | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2003-11-25 | — | — | US | claimed |
| US-6635665-B2 | Acute respiratory distress syndrome and chronic obstructive pulmonary disease | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2003-10-21 | — | — | US | claimed |
| EP-1252889-A1 | REMEDIES OR PREVENTIVES FOR PULMONARY INSUFFICIENCY CONTAINING DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVES | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2002-10-30 | — | — | EP | claimed |
| US-6197796-B1 | Anticancer composition comprising a diaminotrifluoromethylpyridine derivative | ISHIHARA SANGYO KAISHA LTD. (JP) | 2001-03-06 | — | — | US | claimed |
| EP-0971711-A1 | ANTICANCER COMPOSITION COMPRISING A DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVE | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2000-01-19 | — | — | EP | claimed |
| WO-1998037887-A1 | ANTICANCER COMPOSITION COMPRISING A DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVE | ISHIHARA SANGYO KAISHA LTD. (JP) | 1998-09-03 | — | — | WO | claimed |
| EP-0465913-B1 | Diaminotrifluoromethylpyrimidine derivatives, process for their production and phospholipase A2 inhibitor containing them | ISHIHARA SANGYO KAISHA (JP) | 1997-09-10 | — | — | EP | claimed |
| US-5492908-A | ANTIARTHRITIC | ISHIHARA SANGYO KAISHA LTD. (JP) | 1996-02-20 | — | — | US | claimed |
| US-5348967-A | Diaminotrifluoromethylpyridine derivatives, process for their production and phospholipase A2 inhibitor containing them | ISHIHARA SANGYO KAISHA LTD. (JP) | 1994-09-20 | — | — | US | claimed |
| US-5260320-A | Diaminotrifluoromethylpyridine compounds and phospholipase A2 inhibitor containing them | ISHIHARA SANGYO KAISHA LTD. (JP) | 1993-11-09 | — | — | US | claimed |
| US-5229403-A | Enzyme inhibitors, antiinflammatory | ISHIHARA SANGYO KAISHA LTD. (JP) | 1993-07-20 | — | — | US | claimed |
| EP-0465913-A2 | Diaminotrifluoromethylpyrimidine derivatives, process for their production and phospholipase A2 inhibitor containing them | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1992-01-15 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059039-A1 | ANTI-SHOCK AGENT COMPRISING DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVE | LITAF, HSF1, MYD88 | HTT 4856/4885HSD17B10 4605/4885NOS3 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.