Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.38 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | JUN | P05412 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1571444 | 0.93 | SYK (0.38) | MAP4K1MAP4K3GSK3AGSK3BJUN | |
| SCHEMBL13225922 | 0.90 | MAP4K1 (0.39) | MAP4K1MAP4K3GSK3BDGAT1JUN | |
| SCHEMBL1571452 | 0.90 | MAP4K1 (0.39) | MAP4K1MAP4K3PDK2AURKAGSK3A | |
| SCHEMBL1571982 | 0.88 | DDR2 (0.36) | MAP4K1MAP4K3JUNMAPK8MAPK9 | |
| SCHEMBL1571762 | 0.87 | MAP4K1 (0.39) | MAP4K1MAP4K3JUNMAPK8MAPK9 | |
| SCHEMBL1571675 | 0.86 | BRAF (0.36) | MAP4K1MAP4K3PDK2JAK3JAK1 | |
| SCHEMBL1571606 | 0.86 | MAP4K1 (0.38) | MAP4K1MAP4K3JUNMAPK8MAPK9 | |
| SCHEMBL1571877 | 0.86 | MAP4K1 (0.38) | MAP4K1MAP4K3JUNMAPK8MAPK9 | |
| SCHEMBL1572755 | 0.86 | MAP4K1 (0.38) | MAP4K1MAP4K3JUNMAPK8MAPK9 | |
| SCHEMBL1571160 | 0.85 | BRAF (0.51) | MAP4K1MAP4K3JUNMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009153313-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2009-12-23 | — | — | WO | disclosed |