Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Imipramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 13/20 | 0.94 |
| ▸ | SLC6A2 known ✓ | P23975 | 5/20 | 0.94 |
| ▸ | LMNA | P02545 | 4/20 | 0.97 |
| ▸ | MAPT | P10636 | 4/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.97 |
| ▸ | HRH1 | P35367 | 6/20 | 0.94 |
| ▸ | HTR2A | P28223 | 5/20 | 0.94 |
| ▸ | SLC22A1 | O15245 | 4/20 | 0.94 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.94 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.94 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.94 |
| ▸ | DRD2 | P14416 | 4/20 | 0.94 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.94 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.94 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.94 |
| ▸ | HTR2C | P28335 | 4/20 | 0.94 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.94 |
| ▸ | DRD3 | P35462 | 4/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imipramine SCHEMBL41766 | 0.98 | LMNA (1.00) | LMNAMAPTPMP22SMN1; SMN2KDM4E | |
| Imipramine SCHEMBL28759733 | 0.98 | LMNA (1.00) | LMNAMAPTPMP22SMN1; SMN2KDM4E | |
| Imipramine SCHEMBL41765 | 0.98 | LMNA (1.00) | LMNAMAPTPMP22SMN1; SMN2KDM4E | |
| Imipramine SCHEMBL34282 | 0.97 | SLC6A4 (1.00) | LMNAMAPTPMP22SMN1; SMN2KDM4E | |
| Imipramine SCHEMBL17004048 | 0.97 | SLC6A4 (1.00) | LMNAMAPTPMP22SMN1; SMN2KDM4E | |
| Imipramine SCHEMBL29350100 | 0.97 | SLC6A4 (1.00) | LMNAMAPTPMP22SMN1; SMN2KDM4E | |
| Imipramine SCHEMBL6118138 | 0.97 | SLC6A4 (1.00) | LMNAMAPTPMP22SMN1; SMN2KDM4E | |
| Imipramine SCHEMBL29040915 | 0.95 | SLC6A4 (0.97) | LMNAMAPTPMP22SMN1; SMN2KDM4E | |
| Imipramine SCHEMBL27657924 | 0.95 | SLC6A4 (0.97) | LMNAMAPTPMP22SMN1; SMN2KDM4E | |
| Imipramine SCHEMBL3002670 | 0.94 | SLC6A4 (0.94) | LMNAMAPTPMP22SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160287545-A1 | COMPOUND PARTICULARLY FOR TREATING DEPRESSION AND ANXIETY | ZAGGIA, Guerrino (IT) | 2016-10-06 | — | — | US | disclosed |
| EP-2919789-A1 | COMPOUND PARTICULARLY FOR TREATING DEPRESSION AND ANXIETY | Zaggia, Guerrino (IT) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014076643-A1 | COMPOUND PARTICULARLY FOR TREATING DEPRESSION AND ANXIETY | ZAGGIA, Guerrino (IT) | 2014-05-22 | — | — | WO | disclosed |