Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.67 |
| ▸ | KCNJ6 | P48051 | 5/20 | 0.64 |
| ▸ | KCNJ5 | P48544 | 5/20 | 0.64 |
| ▸ | KCNJ3 | P48549 | 5/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.55 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15484911 | 0.89 | KCNJ6 (0.70) | CDK8KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL30010428 | 0.87 | MAPK14 (0.71) | CDK8KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL19303194 | 0.81 | CDK8 (1.00) | CDK8MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL15517839 | 0.81 | CDK8 (0.67) | CDK8KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL15490413 | 0.79 | KCNJ6 (0.65) | CDK8KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL13558462 | 0.78 | KCNJ6 (0.57) | CDK8KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL27780133 | 0.77 | ABL1 (0.48) | CDK8KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL2927100 | 0.76 | MAPK13 (0.51) | CDK8KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL21436480 | 0.76 | CDK8 (0.79) | CDK8MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL4464188 | 0.74 | CDK8 (0.58) | CDK8KCNJ6KCNJ5KCNJ3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925742-A1 | KINASE INHIBITORS | Respivert Limited (GB) | 2015-10-07 | — | — | EP | claimed |
| WO-2014076484-A1 | KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2014-05-22 | — | — | WO | claimed |
| EP-2925742-A1 | KINASE INHIBITORS | Respivert Limited (GB) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014076484-A1 | KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2014-05-22 | — | — | WO | disclosed |