Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.58 |
| ▸ | KCNJ6 | P48051 | 5/20 | 0.49 |
| ▸ | KCNJ5 | P48544 | 5/20 | 0.49 |
| ▸ | KCNJ3 | P48549 | 5/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4470729 | 0.81 | KCNJ6 (0.43) | CDK8KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL4471861 | 0.77 | RAB9A (0.50) | MEN1ALDH1A1LMNAPOLBMAPT | |
| SCHEMBL27741487 | 0.74 | KCNJ6 (0.73) | CDK8KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL15720178 | 0.74 | CDK8 (0.67) | CDK8KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL19303194 | 0.74 | CDK8 (1.00) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL15517839 | 0.74 | CDK8 (0.67) | CDK8KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL21436480 | 0.69 | CDK8 (0.79) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL29397706 | 0.68 | KCNJ6 (0.70) | CDK8KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL3180026 | 0.68 | KCNJ6 (0.51) | CDK8KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL3185815 | 0.68 | KCNJ6 (0.57) | CDK8KCNJ6KCNJ5KCNJ3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582638-B2 | Pyrazole-isoquinoline urea derivatives as p38 kinase inhibitors | ELI LILLY AND COMPANY (US) | 2009-09-01 | — | — | US | disclosed |
| US-20080275056-A1 | With improved potency and greater bioavailability; 1-{1-[1-(1-Methyl-cyclopropanecarbonyl)-piperidin-4-yloxy]-isoquinolin-4-yl}-3-[5-(1-methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-urea; antimetastasis and antineoplastic agents, rheumatoid arthritis | ELI LILLY AND COMPANY | 2008-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275056-A1 | With improved potency and greater bioavailability; 1-{1-[1-(1-Methyl-cyclopropanecarbonyl)-piperidin-4-yloxy]-isoquinolin-4-yl}-3-[5-(1-methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-urea; antimetastasis and antineoplastic agents, rheumatoid arthritis | CNKSR1, CHUK, SLC14A1 | CDK8 244/4885KCNJ6 1986/4885KCNJ5 2326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.