Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 17/20 | 0.49 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | FAP | Q12884 | 2/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.46 |
| ▸ | PREP | P48147 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25068495 | 1.00 | SMYD3 (0.49) | SMYD3DPP4FAPDPP7PREP | |
| SCHEMBL15247318 | 1.00 | SMYD3 (0.49) | SMYD3DPP4FAPDPP7PREP | |
| SCHEMBL14147669 | 0.85 | DPP4 (0.49) | SMYD3DPP4FAPDPP7PREP | |
| SCHEMBL2603237 | 0.83 | MEN1 (0.47) | DPP4DPP7DPP8DPP9MEN1 | |
| SCHEMBL15474125 | 0.83 | DPP4 (0.50) | SMYD3DPP4DPP7PREPDPP8 | |
| SCHEMBL16361183 | 0.83 | DPP4 (0.50) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL15247315 | 0.83 | DPP4 (0.50) | SMYD3DPP4DPP7PREPDPP8 | |
| SCHEMBL15247323 | 0.82 | DPP4 (0.42) | SMYD3DPP4FAPDPP7DPP8 | |
| SCHEMBL13403905 | 0.82 | MEN1 (0.46) | SMYD3DPP4DPP7DPP8DPP9 | |
| SCHEMBL22629569 | 0.82 | ALDH1A1 (0.66) | SMYD3DPP4FAPDPP7PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2815750-A1 | 5-cyano-4-(pyrrolo [2,3b] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors | Vertex Pharmaceuticals Incorporated (US) | 2014-12-24 | — | — | EP | disclosed |
| EP-2124951-B1 | 5-CYAN0-4- (PYRROLO[2, 3B]PYRIDINE-3-YL) -PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2014-05-21 | — | — | EP | disclosed |