Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 7/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 5/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572062 | 0.85 | BRAF (0.53) | BRAFFGFR1SRCAXLABL1 | |
| SCHEMBL13336034 | 0.75 | MAP4K1 (0.42) | BRAFGSK3BDYRK1AKDR | |
| SCHEMBL1571160 | 0.75 | BRAF (0.51) | BRAFFGFR1SRCAXLABL1 | |
| SCHEMBL13336031 | 0.74 | MAP4K1 (0.42) | BRAFGSK3BDYRK1AACHEKDR | |
| SCHEMBL13336194 | 0.74 | MAP4K1 (0.41) | BRAFFGFR1CCNA2CDK2TTK | |
| SCHEMBL1571456 | 0.73 | MAP4K1 (0.40) | BRAFFGFR1CCNA2CDK2TTK | |
| SCHEMBL1571949 | 0.73 | GSK3B (0.42) | BRAFFGFR1CLK2CLK3GSK3B | |
| SCHEMBL13363267 | 0.72 | BRAF (0.54) | BRAFFGFR1SRCACHEAXL | |
| SCHEMBL1571076 | 0.70 | PDK2 (0.41) | BRAFFGFR1KDR | |
| SCHEMBL13225920 | 0.70 | MAP4K1 (0.43) | BRAFCCNA2CDK2TTKIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307385-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | Novartis AG (CH) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009153313-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2009-12-23 | — | — | WO | disclosed |