Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.54 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 11/20 | 0.44 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
| ▸ | YES1 | P07947 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572062 | 0.87 | BRAF (0.53) | BRAFAXLSRCMAP4K3MAP4K1 | |
| SCHEMBL1571160 | 0.85 | BRAF (0.51) | BRAFAXLSRCMAP4K3MAP4K1 | |
| SCHEMBL13573972 | 0.85 | MAP4K1 (0.44) | BRAFACHEMAP4K3MAP4K1SYK | |
| SCHEMBL13251922 | 0.84 | BRAF (0.44) | BRAFAXLSRCMAP4K3MAP4K1 | |
| SCHEMBL13573976 | 0.84 | MAP4K1 (0.44) | BRAFACHEMAP4K3MAP4K1SYK | |
| SCHEMBL13363037 | 0.82 | MAP4K1 (0.41) | MAP4K3MAP4K1KDRJAK1TYK2 | |
| SCHEMBL13363036 | 0.82 | BRAF (0.42) | BRAFMAP4K3MAP4K1KDRSYK | |
| SCHEMBL13363015 | 0.82 | BRAF (0.40) | BRAFMAP4K3MAP4K1KDRFGFR1 | |
| SCHEMBL13363019 | 0.80 | GSK3B (0.40) | BRAFMAP4K3MAP4K1RAF1 | |
| SCHEMBL13362656 | 0.80 | MAP4K1 (0.44) | MAP4K3MAP4K1BRD4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | JAIN RAMA | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | PDK1, PDK2, PDK3 | BRAF 208/4885ACHE 4841/4885AXL 4555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.