Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 7/20 | 0.56 |
| ▸ | AURKA | O14965 | 6/20 | 0.56 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PCTP | Q9UKL6 | 1/20 | 0.42 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 3/20 | 0.42 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1056600 | 0.94 | AURKB (0.48) | AURKBAURKAJAK2JAK1BDKRB1 | |
| SCHEMBL1052804 | 0.87 | AURKB (0.56) | AURKBAURKAJAK2JAK1SRC | |
| SCHEMBL12102863 | 0.86 | AURKA (0.51) | AURKBAURKAJAK2JAK1GRM4 | |
| SCHEMBL13004613 | 0.85 | AURKB (0.47) | AURKBAURKAJAK2JAK1SRC | |
| SCHEMBL13004050 | 0.85 | AURKB (0.47) | AURKBAURKAJAK2JAK1SRC | |
| SCHEMBL13004282 | 0.84 | PTGES (0.41) | AURKBAURKAJAK2JAK1BDKRB1 | |
| SCHEMBL13004609 | 0.84 | AURKB (0.45) | AURKBAURKAJAK2JAK1SRC | |
| SCHEMBL13299472 | 0.84 | AURKB (0.48) | AURKBAURKAJAK2JAK1SRC | |
| SCHEMBL13004614 | 0.82 | AURKB (0.44) | AURKBAURKAJAK2JAK1SRC | |
| SCHEMBL12931472 | 0.81 | AURKB (0.54) | AURKBAURKAJAK2JAK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140141099-A1 | DRUG DISCOVERY METHODS | VERTEX PHARMACEUTICALS INCORPORATED | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140141099-A1 | DRUG DISCOVERY METHODS | AURKB, AURKC, AURKA | AURKB 1/4885AURKA 3/4885JAK2 2547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.