Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 19/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 19/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572415 | 1.00 | HCRTR1 (0.49) | HCRTR1HCRTR2KDM4EALDH1A1HPGD | |
| SCHEMBL1572124 | 0.91 | HCRTR1 (0.55) | HCRTR1HCRTR2 | |
| SCHEMBL1572128 | 0.91 | HCRTR1 (0.55) | HCRTR1HCRTR2 | |
| SCHEMBL1572299 | 0.91 | HCRTR1 (0.55) | HCRTR1HCRTR2 | |
| SCHEMBL1572131 | 0.88 | HCRTR1 (0.41) | HCRTR1HCRTR2KDM4EALDH1A1HPGD | |
| SCHEMBL1572129 | 0.88 | HCRTR1 (0.41) | HCRTR1HCRTR2KDM4EALDH1A1HPGD | |
| SCHEMBL13254696 | 0.88 | HCRTR1 (0.50) | HCRTR1HCRTR2KDM4EALDH1A1HPGD | |
| SCHEMBL1571946 | 0.85 | HCRTR1 (0.56) | HCRTR1HCRTR2 | |
| SCHEMBL13254749 | 0.83 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL1572834 | 0.82 | HCRTR1 (0.48) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288435-B2 | 2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-10-16 | — | — | US | claimed |
| EP-2094690-B1 | 2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-04-13 | — | — | EP | claimed |
| US-8288435-B2 | 2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-10-16 | — | — | US | disclosed |