Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 7/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15725873 | 0.94 | EGFR (0.49) | ALKFGFR3KCNH2FGFR1FGFR4 | |
| SCHEMBL15709889 | 0.89 | FGFR3 (0.57) | FGFR3KCNH2FGFR1FGFR4FGFR2 | |
| SCHEMBL15244057 | 0.89 | IGF1R (0.53) | ALKFGFR3KCNH2FGFR1FGFR4 | |
| SCHEMBL15244368 | 0.84 | FGFR3 (0.54) | FGFR3KCNH2FGFR1FGFR4FGFR2 | |
| SCHEMBL18132625 | 0.83 | IGF1R (0.50) | ALKFGFR3KCNH2FGFR1FGFR4 | |
| SCHEMBL15728454 | 0.82 | FGFR3 (0.59) | FGFR3KCNH2FGFR1FGFR4FGFR2 | |
| SCHEMBL15728403 | 0.82 | FGFR3 (0.57) | FGFR3KCNH2FGFR1FGFR4FGFR2 | |
| SCHEMBL15728535 | 0.81 | FGFR3 (0.52) | FGFR3KCNH2FGFR1FGFR4FGFR2 | |
| SCHEMBL15728676 | 0.79 | FGFR3 (0.56) | FGFR3KCNH2FGFR1FGFR4FGFR2 | |
| SCHEMBL30957984 | 0.78 | EGFR (0.63) | ALKKCNH2EGFRIGF1RMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140142084-A1 | NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND | KOTOBUKI PHARMACEUTICAL CO., LTD. (JP) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142084-A1 | NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND | FGFR3, FGFR1, FGFR2 | ALK 17/4885FGFR3 1/4885KCNH2 3097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.