Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.30 |
| ▸ | CA4 | P22748 | 2/20 | 0.30 |
| ▸ | CA5A | P35218 | 2/20 | 0.30 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL2014213 | 0.95 | — | — | |
| Phosphoric Acid SCHEMBL967 | 0.95 | — | — | |
| Phosphoric Acid SCHEMBL440542 | 0.95 | SLC34A1 (0.64) | SLC34A1LMNAKDM4ECYP2C19KMT2A | |
| Phosphoric Acid SCHEMBL5863257 | 0.95 | SLC34A1 (0.64) | SLC34A1LMNAKDM4ECYP2C19KMT2A | |
| Phosphoric Acid SCHEMBL7870436 | 0.95 | SLC34A1 (0.64) | SLC34A1LMNAKDM4ECYP2C19KMT2A | |
| Phosphoric Acid SCHEMBL6355824 | 0.91 | — | — | |
| Phosphoric Acid SCHEMBL3917721 | 0.90 | SLC34A1 (0.58) | SLC34A1LMNAKDM4ECYP2C19KMT2A | |
| Phosphoric Acid SCHEMBL1572982 | 0.90 | — | — | |
| Phosphoric Acid SCHEMBL1742995 | 0.90 | SLC34A1 (0.58) | SLC34A1LMNAKDM4ECYP2C19KMT2A | |
| Phosphoric Acid SCHEMBL3306696 | 0.90 | SLC34A1 (0.58) | SLC34A1LMNAKDM4ECYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440737-B2 | Composition for injectable cement useful as bone replacement | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-05-14 | — | — | US | claimed |
| EP-1742676-B1 | COMPOSITION FOR INJECTABLE CEMENT USEFUL AS BONE REPLACEMENT | CENTRE NAT RECH SCIENT (FR) | 2011-04-13 | — | — | EP | claimed |
| US-20080027455-A1 | Composition for Injectable Cement Useful as Bone Replacement | UNIVERSITÉ DE MONTPELLIER (FR) | 2008-01-31 | — | — | US | claimed |
| CN-1323726-C | Strontium apatite bone cement preparation and application thereof | KYPHON INC (US) | 2007-07-04 | — | — | CN | claimed |
| CN-1658913-A | Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof | KYPHON INC (US) | 2005-08-24 | — | — | CN | claimed |
| US-8440737-B2 | Composition for injectable cement useful as bone replacement | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-05-14 | — | — | US | disclosed |
| CN-101715350-A | Strontium fortified calcium nanoparticle and microparticle compositions and methods of making and using the same | UNIV HONG KONG | 2010-05-26 | — | — | CN | disclosed |
| EP-2164533-A1 | STRONTIUM FORTIFIED CALCIUM NANO- AND MICROPARTICLE COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF | The University of Hong Kong (CN) | 2010-03-24 | — | — | EP | disclosed |
| WO-2009000158-A1 | STRONTIUM FORTIFIED CALCIUM NANO- AND MICROPARTICLE COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF | THE UNIVERSITY OF HONG KONG (CN) | 2008-12-31 | — | — | WO | disclosed |
| US-20080317807-A1 | STRONTIUM FORTIFIED CALCIUM NANO-AND MICROPARTICLE COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF | THE UNIVERSITY OF HONG KONG | 2008-12-25 | — | — | US | disclosed |
| US-20080027455-A1 | Composition for Injectable Cement Useful as Bone Replacement | UNIVERSITÉ DE MONTPELLIER (FR) | 2008-01-31 | — | — | US | disclosed |
| CN-1323726-C | Strontium apatite bone cement preparation and application thereof | KYPHON INC (US) | 2007-07-04 | — | — | CN | disclosed |
| CN-1658913-A | Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof | KYPHON INC (US) | 2005-08-24 | — | — | CN | disclosed |