Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.68 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.68 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.53 |
| ▸ | PLK1 | P53350 | 2/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15730183 | 0.84 | MKNK1 (0.55) | MKNK1MKNK2RIPK1PLK1DHODH | |
| SCHEMBL15730264 | 0.84 | MKNK1 (0.51) | MKNK1MKNK2RIPK1PLK1HDAC6 | |
| SCHEMBL15723882 | 0.82 | MKNK1 (0.52) | MKNK1MKNK2RIPK1PLK1RPS6KA3 | |
| SCHEMBL15730260 | 0.81 | MKNK1 (0.49) | MKNK1MKNK2RIPK1PLK1RPS6KA3 | |
| SCHEMBL15730267 | 0.81 | MKNK1 (1.00) | MKNK1MKNK2RIPK1DHODHCHEK2 | |
| SCHEMBL23501959 | 0.81 | MKNK1 (0.51) | MKNK1MKNK2RIPK1PLK1RPS6KA3 | |
| SCHEMBL17066911 | 0.81 | MKNK1 (0.51) | MKNK1MKNK2RIPK1PLK1RPS6KA3 | |
| SCHEMBL12954793 | 0.80 | MKNK1 (0.60) | MKNK1MKNK2RIPK1PLK1HDAC6 | |
| SCHEMBL15730265 | 0.78 | MKNK1 (0.68) | MKNK1MKNK2DHODHCHEK2HPGD | |
| SCHEMBL18853780 | 0.77 | PDK2 (0.49) | MKNK1MKNK2DHODHP2RX7ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170137405-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. | 2017-05-18 | — | — | US | disclosed |
| US-9540343-B2 | Compounds for the treatment of HIV | GILEAD SCIENCES, INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-20140142085-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. (US) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170137405-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | CCR5, NPC1, FURIN | MKNK1 2159/4885MKNK2 2342/4885RIPK1 2275/4885 |
| US-20140142085-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | CCR5, NPC1, FURIN | MKNK1 2159/4885MKNK2 2342/4885RIPK1 2275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.