Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 5/20 | 0.36 |
| ▸ | NOS2 | P35228 | 4/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | SELE | P16581 | 1/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18103469 | 0.82 | CYP11B1 (0.42) | CYP11B1CYP11B2LMNATP53ICAM1 | |
| SCHEMBL18100993 | 0.78 | CYP11B1 (0.40) | CYP11B1CYP11B2LMNATP53NOS1 | |
| SCHEMBL15715989 | 0.77 | F2 (0.45) | LMNATP53CA2PDE10A | |
| SCHEMBL30702003 | 0.75 | CYP11B1 (0.51) | CYP11B1CYP11B2PDE10A | |
| SCHEMBL27192178 | 0.75 | CYP11B1 (0.51) | CYP11B1CYP11B2PDE10A | |
| SCHEMBL15732195 | 0.73 | MAOA (0.45) | LMNATP53CA2PDE10AMAOA | |
| SCHEMBL15732198 | 0.72 | MAPT (0.39) | LMNATP53PDE10AMAOADYRK1A | |
| SCHEMBL30702109 | 0.72 | TDP1 (0.41) | LMNATP53IMPDH2 | |
| SCHEMBL8286180 | 0.72 | TDP1 (0.41) | LMNATP53IMPDH2 | |
| SCHEMBL27191756 | 0.72 | CYP3A4 (0.46) | CYP11B1CYP11B2LMNACA2IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014078328-A1 | N-BICYCLIC ARYL,N'-PYRAZOLYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2014-05-22 | — | — | WO | disclosed |