Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.63 |
| ▸ | SOAT1 | P35610 | 11/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 3/20 | 0.44 |
| ▸ | S100A4 | P26447 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15732933 | 1.00 | PTPN1 (0.63) | PTPN1SOAT1ACHEBACE1CNR1 | |
| SCHEMBL15732974 | 1.00 | PTPN1 (0.63) | PTPN1SOAT1ACHEBACE1CNR1 | |
| SCHEMBL15732985 | 1.00 | PTPN1 (0.63) | PTPN1SOAT1ACHEBACE1CNR1 | |
| SCHEMBL15733081 | 1.00 | PTPN1 (0.63) | PTPN1SOAT1ACHEBACE1CNR1 | |
| SCHEMBL15732842 | 0.98 | PTPN1 (0.60) | PTPN1SOAT1ACHEBACE1CNR1 | |
| SCHEMBL15733045 | 0.94 | PTPN1 (0.54) | PTPN1SOAT1S100A4 | |
| SCHEMBL7106795 | 0.87 | PTPN1 (0.45) | PTPN1SOAT1S100A4 | |
| SCHEMBL4848431 | 0.86 | PTPN1 (0.69) | PTPN1SOAT1ACHEBACE1CNR1 | |
| SCHEMBL10786305 | 0.84 | PTPN1 (0.77) | PTPN1SOAT1ACHEBACE1CNR1 | |
| SCHEMBL14307231 | 0.84 | PTPN1 (0.77) | PTPN1SOAT1ACHEBACE1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3182129-B1 | METHOD OF SCREENING A THERAPEUTIC AGENT FOR K-RAS MUTANT CANCER | RAND BIO SCIENCE INC (KR) | 2018-12-26 | — | — | EP | disclosed |
| EP-3182129-A1 | CHEMICAL INHIBITOR OF P53-SNAIL BINDING AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER DISEASE CONTAINING SAME AS ITS ACTIVE INGREDIENT | RAND Bio Science Inc. (KR) | 2017-06-21 | — | — | EP | disclosed |
| US-9400281-B2 | Method of screening of therapeutic agents for K-Ras mutant driven cancers | PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (KR) | 2016-07-26 | — | — | US | disclosed |
| US-20140147866-A1 | COMPOUND FOR INHIBITING SNAIL-P53 BINDING AND THERAPEUTIC AGENT FOR CANCER INCLUDING THE COMPOUND AS EFFECTIVE COMPONENT | THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (KR) | 2014-05-29 | — | — | US | disclosed |