Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.69 |
| ▸ | CNR1 | P21554 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 10/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15732842 | 0.87 | PTPN1 (0.60) | PTPN1CNR1ACHEBACE1SOAT1 | |
| SCHEMBL15733081 | 0.86 | PTPN1 (0.63) | PTPN1CNR1ACHEBACE1SOAT1 | |
| SCHEMBL15732933 | 0.86 | PTPN1 (0.63) | PTPN1CNR1ACHEBACE1SOAT1 | |
| SCHEMBL15732985 | 0.86 | PTPN1 (0.63) | PTPN1CNR1ACHEBACE1SOAT1 | |
| SCHEMBL15732974 | 0.86 | PTPN1 (0.63) | PTPN1CNR1ACHEBACE1SOAT1 | |
| SCHEMBL15732809 | 0.86 | PTPN1 (0.63) | PTPN1CNR1ACHEBACE1SOAT1 | |
| SCHEMBL15733045 | 0.82 | PTPN1 (0.54) | PTPN1SOAT1APAF1ALDH1A1S100A4 | |
| SCHEMBL8163726 | 0.77 | PTPN1 (0.73) | PTPN1ACHEBACE1SOAT1APAF1 | |
| SCHEMBL10786305 | 0.75 | PTPN1 (0.77) | PTPN1CNR1ACHEBACE1SOAT1 | |
| SCHEMBL9628184 | 0.75 | PTPN1 (0.77) | PTPN1CNR1ACHEBACE1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008066300-A1 | NAPHTHOQUINONE-BASED PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF DISEASES INVOLVING OBESITY, DIABETES, METABOLIC SYNDROME, NEURO-DEGENERATIVE DISEASES AND MITOCHONDRIA DYSFUNCTION DISEASES | MAZENCE INC. (KR) | 2008-06-05 | — | — | WO | disclosed |