⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30494611 | 1.00 | — | — | |
| SCHEMBL30494589 | 1.00 | — | — | |
| SCHEMBL157376 | 1.00 | — | — | |
| SCHEMBL8427210 | 0.90 | — | — | |
| SCHEMBL9472459 | 0.86 | — | — | |
| SCHEMBL9472457 | 0.86 | — | — | |
| SCHEMBL8532662 | 0.86 | — | — | |
| SCHEMBL9293941 | 0.86 | — | — | |
| SCHEMBL8533700 | 0.86 | — | — | |
| SCHEMBL8532769 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 158 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0489547-B1 | A process for the preparation of a 3-alkylated indole, intermediates, and a process for the preparation of a derivative thereof | ZENECA LTD (GB) | 1998-07-29 | — | — | EP | claimed |
| EP-0432984-B1 | Carbamoyl derivatives | ZENECA LTD (GB) | 1998-03-04 | — | — | EP | claimed |
| US-5466826-A | Crystallization of indole derivative from solvents as antiasthmatics | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1995-11-14 | — | — | US | claimed |
| US-5352694-A | 3-methoxy-4(1-methyl-5(2-methyl-4,4,4-trifluorobutylcarbamoyl) indole-3-ylmethyl)-N-(2-methylphenylsulphonyl) benzamide; leukotriene antagonist used for asthma treatment | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-10-04 | — | — | US | claimed |
| US-5286740-A | Leukotrine antagonists; antiinflammatory agnets, antiallergens, treating asthma | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-02-15 | — | — | US | claimed |
| US-5274118-A | Process for preparing (2R)-methyl-4,4,4-trifluorobutylamine | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-28 | — | — | US | claimed |
| EP-0489547-A1 | A process for the preparation of a 3-alkylated indole, intermediates, and a process for the preparation of a derivative thereof | ZENECA LIMITED (GB) | 1992-06-10 | — | — | EP | claimed |
| EP-0432984-A2 | Carbamoyl derivatives | ZENECA LIMITED (GB) | 1991-06-19 | — | — | EP | claimed |
| JP-7070061-A | — | — | None | — | — | JP | disclosed |
| JP-5194385-A | — | — | None | — | — | JP | disclosed |
| US-20250092042-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2025-03-20 | — | — | US | disclosed |
| US-20220008400-A1 | METHODS OF TREATING AUTOIMMUNE, RESPIRATORY AND INFLAMMATORY DISORDERS BY INHALATION OF ROFLUMILAST N-OXIDE | INCOZEN THERAPEUTICS PVT LTD (IN) | 2022-01-13 | — | — | US | disclosed |
| EP-3763366-A1 | ROFLUMILAST N-OXIDE FOR USE IN TREATING AUTOIMMUNE, RESPIRATORY AND INFLAMMATORY DISORDERS BY INHALATION | Incozen Therapeutics Pvt. Ltd. (IN) | 2021-01-13 | — | — | EP | disclosed |
| EP-2948148-B1 | METHODS OF TREATING AUTOIMMUNE, RESPIRATORY AND INFLAMMATORY DISORDERS BY INHALATION OF ROFLUMILAST N-OXIDE | INCOZEN THERAPEUTICS PVT LTD (IN) | 2020-07-29 | — | — | EP | disclosed |
| US-5274118-A | Process for preparing (2R)-methyl-4,4,4-trifluorobutylamine | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-28 | — | — | US | disclosed |
| US-5274118-A | Process for preparing (2R)-methyl-4,4,4-trifluorobutylamine | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-28 | — | — | US | disclosed |
| JP-H05194385-A | PHARMACEUTICAL AGENT | IMPERIAL CHEM IND PLC <ICI> | 1993-08-03 | — | — | JP | disclosed |
| EP-0489548-A1 | A process for the preparation of 2(R)-methyl-4,4,4-trifluorobutylamine, intermediates, and a process for the preparation of a derivative thereof | ZENECA LIMITED (GB) | 1992-06-10 | — | — | EP | disclosed |
| EP-0489547-A1 | A process for the preparation of a 3-alkylated indole, intermediates, and a process for the preparation of a derivative thereof | ZENECA LIMITED (GB) | 1992-06-10 | — | — | EP | disclosed |
| EP-0432984-A2 | Carbamoyl derivatives | ZENECA LIMITED (GB) | 1991-06-19 | — | — | EP | disclosed |