Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 19/20 | 0.84 |
| ▸ | IKBKE | Q14164 | 11/20 | 0.64 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14058973 | 0.91 | TBK1 (1.00) | TBK1IKBKE | |
| SCHEMBL15737678 | 0.86 | TBK1 (0.84) | TBK1IKBKE | |
| SCHEMBL15738880 | 0.83 | TBK1 (0.85) | TBK1IKBKE | |
| SCHEMBL14059342 | 0.82 | TBK1 (0.80) | TBK1IKBKE | |
| SCHEMBL15736400 | 0.81 | TBK1 (0.85) | TBK1IKBKE | |
| SCHEMBL15737750 | 0.79 | TBK1 (0.83) | TBK1IKBKE | |
| SCHEMBL15736046 | 0.78 | TBK1 (0.63) | TBK1IKBKEMKNK1MKNK2 | |
| SCHEMBL15738293 | 0.78 | TBK1 (0.85) | TBK1IKBKE | |
| SCHEMBL14059032 | 0.78 | TBK1 (1.00) | TBK1IKBKE | |
| SCHEMBL15738513 | 0.77 | TBK1 (0.82) | TBK1IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249114-B2 | Thiazole derivatives | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | claimed |
| US-20140148457-A1 | Thiazole derivatives | MERCK PATENT GMBH (DE) | 2014-05-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148457-A1 | Thiazole derivatives | TBK1, IRAK1, IRF3 | TBK1 1/4885IKBKE 17/4885MKNK1 772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.