Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573923 | 1.00 | KDM4E (0.44) | KDM4EGAAMAPTHDAC1HDAC2 | |
| SCHEMBL4396685 | 0.89 | GAA (0.50) | KDM4EGAAMAPTHDAC1HDAC2 | |
| SCHEMBL7226906 | 0.89 | GAA (0.50) | KDM4EGAAMAPTHDAC1HDAC2 | |
| SCHEMBL7237208 | 0.89 | GAA (0.50) | KDM4EGAAMAPTHDAC1HDAC2 | |
| SCHEMBL1573769 | 0.80 | MAPK1 (0.48) | GAAMAPTMAPK1NPC1RAB9A | |
| SCHEMBL1573767 | 0.80 | MAPK1 (0.48) | GAAMAPTMAPK1NPC1RAB9A | |
| SCHEMBL13221824 | 0.76 | KDM4E (0.59) | KDM4EGAAMAPTHDAC1HDAC2 | |
| SCHEMBL15854061 | 0.76 | KDM4E (0.48) | KDM4EGAAMAPTHDAC1HDAC2 | |
| SCHEMBL17030967 | 0.76 | KDM4E (0.48) | KDM4EGAAMAPTHDAC1HDAC2 | |
| SCHEMBL17030966 | 0.76 | KDM4E (0.48) | KDM4EGAAMAPTHDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140085-B1 | AZABICYCLOALKANES AS CCR5 MODULATORS | PHIVCO UK LTD (GB) | 2011-04-13 | — | — | EP | disclosed |
| US-6586430-B1 | Administering azabicyclo compounds to treat human immunodeficiency virus infections and respiratory system disorders | PFIZER INC. | 2003-07-01 | — | — | US | disclosed |