Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | HTR2B | P41595 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29185139 | 1.00 | POLB (0.47) | POLBHTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL8916490 | 0.90 | SMN1; SMN2 (0.52) | POLBHTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL2697384 | 0.90 | SMN1; SMN2 (0.52) | POLBHTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL2697385 | 0.90 | SMN1; SMN2 (0.52) | POLBHTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL30039829 | 0.86 | HTR2A (0.37) | POLBHTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL20893422 | 0.83 | HTR2A (0.38) | POLBHTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL30153867 | 0.82 | POLB (0.41) | POLBHTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL18909623 | 0.81 | HTR2A (0.34) | POLBHTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL31269358 | 0.80 | HTR2A (0.35) | POLBHTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL30154000 | 0.80 | HTR2A (0.35) | POLBHTR2AHTR2CHTR2BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304602-A | Pyrazinopyrazinonaphthyridinedione derivatives, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2022-11-08 | — | — | CN | disclosed |
| WO-2016004272-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2016-01-07 | — | — | WO | disclosed |
| WO-2016004305-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2016-01-07 | — | — | WO | disclosed |
| WO-2014078578-A1 | PYRROLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | PHARMACYCLICS, INC. (US) | 2014-05-22 | — | — | WO | disclosed |