Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.33 |
| ▸ | MTOR | P42345 | 7/20 | 0.33 |
| ▸ | ACHE | P22303 | 3/20 | 0.32 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | RICTOR | Q6R327 | 3/20 | 0.30 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.30 |
| ▸ | MAPKAP1 | Q9BPZ7 | 3/20 | 0.30 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.30 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4949146 | 0.78 | MTOR (0.45) | KDM1APIK3CAMTOROGAPIK3CB | |
| SCHEMBL23593409 | 0.76 | KDM1A (0.46) | KDM1APIK3CAOGADYRK1APIK3R1 | |
| SCHEMBL23593427 | 0.75 | KDM1A (0.39) | KDM1APIK3CAMTOROGADYRK1A | |
| SCHEMBL10187282 | 0.70 | DYRK1A (0.49) | KDM1AOGADYRK1AMKNK1MKNK2 | |
| SCHEMBL21354081 | 0.69 | MTOR (0.75) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL23579408 | 0.67 | KDM1A (0.42) | KDM1APIK3CAOGADYRK1APIK3R1 | |
| SCHEMBL29959199 | 0.67 | KDM1A (0.42) | KDM1APIK3CAOGADYRK1APIK3R1 | |
| SCHEMBL9900073 | 0.67 | KDM1A (0.47) | KDM1APIK3CAACHEOGADYRK1A | |
| SCHEMBL23579347 | 0.67 | KDM1A (0.40) | KDM1APIK3CAOGADYRK1APIK3R1 | |
| SCHEMBL23593411 | 0.67 | KDM1A (0.40) | KDM1APIK3CAOGADYRK1APIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922851-A1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | Genentech, Inc. (US) | 2015-09-30 | — | — | EP | disclosed |
| WO-2014081718-A1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | GENENTECH, INC. (US) | 2014-05-30 | — | — | WO | disclosed |