Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.40 |
| ▸ | MTOR | P42345 | 6/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 11/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15744120 | 0.76 | PIK3CA (0.67) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL6749633 | 0.74 | PIK3CA (0.44) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL6750903 | 0.73 | PIK3CA (0.44) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL623972 | 0.67 | PIK3CA (0.60) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL3401685 | 0.65 | PIK3CA (0.49) | PIK3CAPIK3R1 | |
| SCHEMBL3398660 | 0.64 | PIK3CA (0.48) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL15744123 | 0.64 | PIK3CA (0.38) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL10298274 | 0.62 | ALDH1A1 (0.50) | PIK3CAMTOR | |
| SCHEMBL624130 | 0.62 | KDM4E (0.47) | PIK3CA | |
| SCHEMBL3766049 | 0.61 | PIK3CA (0.46) | PIK3CAMTORPIK3R1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313399-B1 | THIOPHENE OR THIAZOLE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS | MILLENNIUM PHARM INC (US) | 2014-05-28 | — | — | EP | disclosed |