Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.56 |
| ▸ | MTOR | P42345 | 4/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17244452 | 0.78 | PIK3CA (0.62) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL7996325 | 0.77 | PIK3CA (0.64) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1550849 | 0.75 | PIK3CA (0.60) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1552109 | 0.75 | PIK3CA (0.64) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1552152 | 0.74 | PIK3CA (0.69) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1551282 | 0.74 | PIK3CA (0.74) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL8005706 | 0.74 | PIK3CA (0.58) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL15744120 | 0.73 | PIK3CA (0.67) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1552029 | 0.73 | PIK3CA (0.64) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1551287 | 0.73 | PIK3CA (0.74) | PIK3CAMTORPIK3R1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313399-B1 | THIOPHENE OR THIAZOLE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS | MILLENNIUM PHARM INC (US) | 2014-05-28 | — | — | EP | disclosed |