Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.36 |
| ▸ | C1S | P09871 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23992891 | 0.83 | KDM4E (0.42) | KDM4EGLAMAPTPOLBPLAU | |
| SCHEMBL15248274 | 0.79 | KDM4E (0.57) | KDM4EGLAMAPTPOLBPLAU | |
| SCHEMBL17177294 | 0.79 | KDM4E (0.57) | KDM4EGLAMAPTPOLBPLAU | |
| SCHEMBL6707733 | 0.78 | KDM4E (0.55) | KDM4EGLAMAPTPOLBPLAU | |
| SCHEMBL20204052 | 0.75 | KEAP1 (0.34) | KDM4EGLAMAPTPOLBKMT2A | |
| SCHEMBL19688933 | 0.75 | KDM4E (0.56) | KDM4EGLAMAPTPOLBPLAU | |
| SCHEMBL16109488 | 0.75 | MAPT (0.69) | KDM4EGLAMAPTPOLBPLAU | |
| SCHEMBL24147311 | 0.75 | KDM4E (0.52) | KDM4EGLAMAPTPOLBPLAU | |
| SCHEMBL18971880 | 0.75 | KDM4E (0.67) | KDM4EGLAMAPTPOLBPLAU | |
| SCHEMBL23236602 | 0.73 | KDM4E (0.50) | KDM4EGLAMAPTPOLBPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150574-A1 | INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS LIPOAMIDE DEHYDROGENASE | CORNELL UNIVERSITY (US) | 2022-07-14 | — | — | WO | disclosed |
| EP-2735562-A1 | Estrogen receptor modulators and uses thereof | Seragon Pharmaceuticals, Inc. (US) | 2014-05-28 | — | — | EP | disclosed |