SCHEMBL15744885

SCHEMBL15744885

CCCc1ccc(-c2cc(F)c(CCc3cc(F)c(C(F)(F)OC(F)(F)F)c(F)c3)c(F)c2)cc1

nearest known ligand 0.34

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RARB P10826 2/20 0.34
RARA P10276 1/20 0.34
RARG P13631 1/20 0.34
CYP17A1 P05093 1/20 0.33
CYP21A2 P08686 1/20 0.33
CYP11B1 P15538 1/20 0.33
NPC1 O15118 1/20 0.32
TP53 P04637 1/20 0.32
PKM P14618 1/20 0.32
RAB9A P51151 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HSD17B10 Q99714 1/20 0.32
MCL1 Q07820 1/20 0.32
FFAR4 Q5NUL3 2/20 0.31
KIF11 P52732 1/20 0.31
CHKA P35790 1/20 0.30
DAO P14920 1/20 0.30
MAOB P27338 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15744334 0.92 RARB (0.38) RARBRARARARGCYP17A1CYP21A2
SCHEMBL15744557 0.92 RARB (0.38) RARBRARARARGCYP17A1CYP21A2
SCHEMBL15745179 0.92 MCL1 (0.35) RARBRARARARGCYP17A1CYP21A2
SCHEMBL15744374 0.91 RARB (0.39) RARBRARARARGCYP17A1CYP21A2
SCHEMBL15744349 0.91 RARB (0.39) RARBRARARARGCYP17A1CYP21A2
SCHEMBL15744316 0.91 RARB (0.39) RARBRARARARGCYP17A1CYP21A2
SCHEMBL15744408 0.88 THRB (0.34) NPC1TP53PKMRAB9ASMN1; SMN2
SCHEMBL15744983 0.87 DAO (0.32) DAO
SCHEMBL15744562 0.87 DAO (0.32) DAO
SCHEMBL15744511 0.87 DAO (0.32) DAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9365774-B2 Liquid crystal compound having CF2OCF3 at terminal, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2016-06-14 US disclosed
US-9365774-B2 Liquid crystal compound having CF2OCF3 at terminal, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2016-06-14 US disclosed
US-20140145113-A1 LIQUID CRYSTAL COMPOUND HAVING CF2OCF3 AT TERMINAL, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2014-05-29 US disclosed
US-20140145113-A1 LIQUID CRYSTAL COMPOUND HAVING CF2OCF3 AT TERMINAL, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2014-05-29 US disclosed