⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15746197 | 0.69 | — | — | |
| SCHEMBL18726992 | 0.67 | SMN1; SMN2 (0.42) | — | |
| SCHEMBL8132758 | 0.61 | KDM4E (0.32) | — | |
| SCHEMBL15746372 | 0.60 | SMN1; SMN2 (0.37) | — | |
| SCHEMBL17019671 | 0.60 | PDE7A (0.30) | — | |
| SCHEMBL5029748 | 0.60 | DRD4 (0.42) | — | |
| SCHEMBL19322587 | 0.60 | RXRA (0.39) | — | |
| SCHEMBL31598395 | 0.60 | DRD4 (0.42) | — | |
| SCHEMBL9722649 | 0.59 | BRD4 (0.38) | — | |
| SCHEMBL15747100 | 0.59 | HDAC4 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9416139-B2 | Spiro ring compound as hepatitis C virus (HCV) inhibitor and uses thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-08-16 | — | — | US | disclosed |
| US-9303061-B2 | Spiro compounds as Hepatitis C virus inhibitors | Sunshine Luke Pharma Co., Ltd. (CN) | 2016-04-05 | — | — | US | disclosed |
| US-20140147412-A1 | SPIRO COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2014-05-29 | — | — | US | disclosed |