Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.48 |
| ▸ | ATM | Q13315 | 4/20 | 0.48 |
| ▸ | ATR | Q13535 | 3/20 | 0.48 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.44 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15747859 | 0.95 | MTOR (0.50) | MTORPIK3CAATMATRPIK3C2A | |
| SCHEMBL15747892 | 0.94 | MTOR (0.56) | MTORPIK3CAATMATRPIK3C2A | |
| SCHEMBL15747730 | 0.91 | MTOR (0.55) | MTORPIK3CAATMATRPIK3C2A | |
| SCHEMBL15747889 | 0.89 | MTOR (0.47) | MTORPIK3CAATMATRPIK3C2A | |
| SCHEMBL15747811 | 0.89 | ATM (0.52) | MTORPIK3CAATMATRPIK3CD | |
| SCHEMBL15747876 | 0.89 | MTOR (0.45) | MTORPIK3CAATMATRPIK3C2A | |
| SCHEMBL15747851 | 0.89 | MTOR (0.45) | MTORPIK3CAATMATRPIK3C2A | |
| SCHEMBL15747816 | 0.88 | MTOR (0.55) | MTORPIK3CAATMATRPIK3C2A | |
| SCHEMBL15747812 | 0.88 | MTOR (0.57) | MTORPIK3CAATMATRPIK3C2A | |
| SCHEMBL15747763 | 0.87 | PIK3CA (0.42) | MTORPIK3CAATMATRPIK3C2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014079364-A1 | IMIDAZOLONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | 北京富龙康泰生物技术有限公司 (CN) | 2014-05-30 | — | — | WO | disclosed |