Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15750243 | 0.87 | PSEN1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15750314 | 0.87 | MAPT (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL24268410 | 0.85 | MITF (0.30) | — | |
| SCHEMBL15748113 | 0.84 | MAPT (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23636525 | 0.83 | PSEN1 (0.32) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27407298 | 0.83 | MAPT (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23636560 | 0.82 | PSEN1 (0.31) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15747969 | 0.81 | EPHX1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL24268559 | 0.79 | PSEN1 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL24268557 | 0.76 | MAPT (0.32) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922574-B1 | CHEMICALLY CLEAVABLE GROUP | TAGWORKS PHARMACEUTICALS B V (NL) | 2023-05-17 | — | — | EP | disclosed |
| EP-3973993-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | Tagworks Pharmaceuticals B.V. (NL) | 2022-03-30 | — | — | EP | disclosed |
| EP-2709666-B1 | BIO-ORTHOGONAL DRUG ACTIVATION | KONINKLIJKE PHILIPS NV (NL) | 2021-07-14 | — | — | EP | disclosed |
| WO-2014081301-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2014-05-30 | — | — | WO | disclosed |