Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 17/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15743107 | 0.91 | DGAT1 (0.46) | DGAT1 | |
| SCHEMBL15748616 | 0.86 | DGAT1 (0.47) | DGAT1BACE1SMN1; SMN2 | |
| SCHEMBL17195459 | 0.85 | DGAT1 (0.52) | DGAT1BACE1SMN1; SMN2 | |
| SCHEMBL17211841 | 0.85 | DGAT1 (0.52) | DGAT1BACE1SMN1; SMN2 | |
| SCHEMBL15690662 | 0.85 | DGAT1 (0.52) | DGAT1BACE1SMN1; SMN2 | |
| SCHEMBL14137124 | 0.85 | DGAT1 (0.52) | DGAT1BACE1SMN1; SMN2 | |
| SCHEMBL15748678 | 0.83 | DGAT1 (0.50) | DGAT1BACE1SMN1; SMN2 | |
| SCHEMBL15748677 | 0.82 | DGAT1 (0.49) | DGAT1BACE1SMN1; SMN2 | |
| SCHEMBL15748623 | 0.82 | DGAT1 (0.49) | DGAT1BACE1SMN1; SMN2 | |
| SCHEMBL15691860 | 0.81 | DGAT1 (0.50) | DGAT1BACE1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014081995-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-05-30 | — | — | WO | disclosed |