Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15748791 | 0.93 | ALDH1A1 (0.48) | MAPTKDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL15748867 | 0.81 | MAPT (0.52) | MAPTKDM4ETP53ADORA1ALPL | |
| SCHEMBL15748777 | 0.79 | MAPT (0.56) | MAPTTHRB | |
| SCHEMBL15748868 | 0.79 | MAPT (0.53) | MAPTKDM4ETP53LMNAADORA1 | |
| SCHEMBL15748804 | 0.78 | MAPT (0.57) | MAPTKDM4EALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL15748866 | 0.76 | MAPT (0.57) | MAPTKDM4EALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL15748801 | 0.73 | MAPT (0.62) | MAPTKDM4EALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL15748823 | 0.73 | MAPT (0.54) | MAPTTP53NPSR1LMNAPOLB | |
| SCHEMBL15748959 | 0.73 | MAPT (0.54) | MAPTKDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL15748822 | 0.72 | MAPT (0.53) | MAPTKDM4EALDH1A1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9676779-B2 | Small molecule CFTR correctors | DISCOVERYBIOMED, INC. (US) | 2017-06-13 | — | — | US | disclosed |
| US-9676779-B2 | Small molecule CFTR correctors | DISCOVERYBIOMED, INC. (US) | 2017-06-13 | — | — | US | disclosed |
| WO-2014081820-A1 | SMALL MOLECULE CFTR CORRECTORS | DISCOVERYBIOMED, INC. (US) | 2014-05-30 | — | — | WO | disclosed |