Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.42 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 5/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15758904 | 1.00 | OPRM1 (0.42) | OPRM1OPRD1OPRK1OGFRL1GRM5 | |
| Hydrochloric Acid SCHEMBL15754196 | 0.99 | OPRM1 (0.41) | OPRM1OPRD1OPRK1OGFRL1GRM5 | |
| SCHEMBL15758719 | 0.84 | HRH4 (0.46) | OPRM1OPRD1OPRK1OGFRL1AKT1 | |
| SCHEMBL15758329 | 0.84 | ACKR3 (0.52) | OPRM1OPRD1OPRK1OGFRL1AKT1 | |
| SCHEMBL15760241 | 0.84 | HRH4 (0.46) | OPRM1OPRD1OPRK1OGFRL1AKT1 | |
| SCHEMBL15760254 | 0.84 | ACKR3 (0.52) | OPRM1OPRD1OPRK1OGFRL1AKT1 | |
| Hydrochloric Acid SCHEMBL15758737 | 0.83 | HRH4 (0.45) | OPRM1OPRD1OPRK1OGFRL1AKT1 | |
| Hydrochloric Acid SCHEMBL15754831 | 0.83 | ACKR3 (0.52) | OPRM1OPRD1OPRK1OGFRL1MKNK1 | |
| Hydrochloric Acid SCHEMBL15758950 | 0.83 | ACKR3 (0.52) | OPRM1OPRD1OPRK1OGFRL1MKNK1 | |
| Hydrochloric Acid SCHEMBL15753990 | 0.83 | HRH4 (0.45) | OPRM1OPRD1OPRK1OGFRL1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11834452-B2 | CXCR7 antagonists | CHEMOCENTRYX, INC. (US) | 2023-12-05 | — | — | US | disclosed |
| US-11834452-B2 | CXCR7 antagonists | CHEMOCENTRYX, INC. (US) | 2023-12-05 | — | — | US | disclosed |
| US-20220127272-A1 | CXCR7 ANTAGONISTS | CHEMOCENTRYX, INC. | 2022-04-28 | — | — | US | disclosed |
| US-11059825-B2 | CXCR7 antagonists | CHEMOCENTRYX, INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-10287292-B2 | CXCR7 antagonists | CHEMOCENTRYX, INC. (US) | 2019-05-14 | — | — | US | disclosed |
| EP-2925745-B1 | CXCR7 ANTAGONISTS | CHEMOCENTRYX INC (US) | 2018-04-04 | — | — | EP | disclosed |
| US-20180086766-A1 | CXCR7 ANTAGONISTS | CHEMOCENTRYX, INC. | 2018-03-29 | — | — | US | disclosed |
| US-20180086766-A1 | CXCR7 ANTAGONISTS | CHEMOCENTRYX, INC. | 2018-03-29 | — | — | US | disclosed |
| US-9783544-B2 | CXCR7 antagonists | CHEMOCENTRYX, INC. (US) | 2017-10-10 | — | — | US | disclosed |
| US-9783544-B2 | CXCR7 antagonists | CHEMOCENTRYX, INC. (US) | 2017-10-10 | — | — | US | disclosed |
| US-20160145259-A1 | CXCR7 ANTAGONISTS | CHEMOCENTRYX, INC. | 2016-05-26 | — | — | US | disclosed |
| US-20160145259-A1 | CXCR7 ANTAGONISTS | CHEMOCENTRYX, INC. | 2016-05-26 | — | — | US | disclosed |
| US-9169261-B2 | CXCR7 antagonists | CHEMOCENTRYX, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-9169261-B2 | CXCR7 antagonists | CHEMOCENTRYX, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-20140154179-A1 | CXCR7 ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2014-06-05 | — | — | US | disclosed |
| WO-2014085490-A1 | CXCR7 ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2014-06-05 | — | — | WO | disclosed |
| US-20140154179-A1 | CXCR7 ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2014-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10287292-B2 | CXCR7 antagonists | CXCR1, CXCR5, CCR7 | OPRM1 140/4885OPRD1 65/4885OPRK1 94/4885 |
| US-20180086766-A1 | CXCR7 ANTAGONISTS | CXCR1, CXCR5, CCR7 | OPRM1 140/4885OPRD1 65/4885OPRK1 94/4885 |
| US-11059825-B2 | CXCR7 antagonists | CXCR1, CXCR5, CCR7 | OPRM1 140/4885OPRD1 65/4885OPRK1 94/4885 |
| US-20160145259-A1 | CXCR7 ANTAGONISTS | CXCR1, CXCR5, CCR7 | OPRM1 140/4885OPRD1 65/4885OPRK1 94/4885 |
| US-11834452-B2 | CXCR7 antagonists | CXCR1, CXCR5, CCR7 | OPRM1 140/4885OPRD1 65/4885OPRK1 94/4885 |
| US-20140154179-A1 | CXCR7 ANTAGONISTS | CXCR1, CXCR5, CCR7 | OPRM1 140/4885OPRD1 65/4885OPRK1 94/4885 |
| US-20220127272-A1 | CXCR7 ANTAGONISTS | CXCR1, CXCR5, CCR7 | OPRM1 140/4885OPRD1 65/4885OPRK1 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.