Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.81 |
| ▸ | RAB9A | P51151 | 8/20 | 0.81 |
| ▸ | HPGD | P15428 | 1/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.81 |
| ▸ | JAK2 | O60674 | 4/20 | 0.73 |
| ▸ | JAK1 | P23458 | 3/20 | 0.73 |
| ▸ | MAOB | P27338 | 2/20 | 0.67 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.65 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.65 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.65 |
| ▸ | CLK2 | P49760 | 1/20 | 0.65 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.65 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.65 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814633 | 0.93 | RAB9A (0.71) | NPC1RAB9AHPGDSMN1; SMN2JAK2 | |
| SCHEMBL6814643 | 0.87 | NPC1 (0.64) | NPC1RAB9AHPGDSMN1; SMN2JAK2 | |
| SCHEMBL7261149 | 0.87 | NPC1 (0.68) | NPC1RAB9AHPGDSMN1; SMN2JAK2 | |
| SCHEMBL25131975 | 0.86 | NPC1 (0.75) | NPC1RAB9AHPGDSMN1; SMN2JAK2 | |
| SCHEMBL15764662 | 0.85 | NPC1 (1.00) | NPC1RAB9AHPGDSMN1; SMN2JAK2 | |
| SCHEMBL15764657 | 0.85 | JAK2 (1.00) | NPC1RAB9AHPGDJAK2JAK1 | |
| SCHEMBL16888856 | 0.84 | NPC1 (0.64) | NPC1RAB9AHPGDSMN1; SMN2JAK2 | |
| SCHEMBL31070240 | 0.83 | NPC1 (0.67) | NPC1RAB9AHPGDSMN1; SMN2JAK2 | |
| SCHEMBL15764689 | 0.82 | NPC1 (0.70) | NPC1RAB9AHPGDSMN1; SMN2JAK2 | |
| SCHEMBL15764666 | 0.81 | NPC1 (0.81) | NPC1RAB9ASMN1; SMN2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951316-B2 | Enhancers of induced pluripotent stem cell reprogramming | CITY OF HOPE (US) | 2018-04-24 | — | — | US | disclosed |
| US-20150191701-A1 | ENHANCERS OF INDUCED PLURIPOTENT STEM CELL REPROGRAMMING | CITY OF HOPE | 2015-07-09 | — | — | US | disclosed |
| US-8962322-B2 | Enhancers of induced pluripotent stem cell reprogramming | CITY OF HOPE | 2015-02-24 | — | — | US | disclosed |
| US-20140154805-A1 | ENHANCERS OF INDUCED PLURIPOTENT STEM CELL REPROGRAMMING | CITY OF HOPE (US) | 2014-06-05 | — | — | US | disclosed |