Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.73 |
| ▸ | RAB9A | P51151 | 4/20 | 0.73 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.73 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.73 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.73 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.73 |
| ▸ | CLK2 | P49760 | 1/20 | 0.73 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.73 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.73 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.73 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.73 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.73 |
| ▸ | JAK2 | O60674 | 1/20 | 0.70 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | JAK3 | P52333 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15764676 | 0.84 | NPC1 (1.00) | NPC1RAB9ADYRK3ROCK2MAP4K4 | |
| SCHEMBL3380296 | 0.82 | NPC1 (1.00) | NPC1RAB9ADYRK3ROCK2MAP4K4 | |
| SCHEMBL5415117 | 0.82 | MAOB (0.80) | NPC1RAB9ADYRK3ROCK2MAP4K4 | |
| SCHEMBL15764674 | 0.82 | ROCK2 (0.75) | NPC1RAB9ADYRK3ROCK2MAP4K4 | |
| SCHEMBL15764661 | 0.82 | NPC1 (0.74) | NPC1RAB9ADYRK3ROCK2MAP4K4 | |
| SCHEMBL16834423 | 0.81 | NPC1 (0.60) | NPC1RAB9ADYRK3ROCK2MAP4K4 | |
| SCHEMBL6168385 | 0.81 | ESR1 (0.82) | NPC1RAB9AMEN1POLBKMT2A | |
| SCHEMBL29099857 | 0.81 | MEN1 (0.71) | NPC1RAB9ADYRK3ROCK2MAP4K4 | |
| SCHEMBL13198179 | 0.81 | DDR2 (1.00) | DDR2JAK3 | |
| SCHEMBL13198188 | 0.80 | DDR2 (0.70) | DDR2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951316-B2 | Enhancers of induced pluripotent stem cell reprogramming | CITY OF HOPE (US) | 2018-04-24 | — | — | US | disclosed |
| US-20150191701-A1 | ENHANCERS OF INDUCED PLURIPOTENT STEM CELL REPROGRAMMING | CITY OF HOPE | 2015-07-09 | — | — | US | disclosed |
| US-8962322-B2 | Enhancers of induced pluripotent stem cell reprogramming | CITY OF HOPE | 2015-02-24 | — | — | US | disclosed |
| US-20140154805-A1 | ENHANCERS OF INDUCED PLURIPOTENT STEM CELL REPROGRAMMING | CITY OF HOPE (US) | 2014-06-05 | — | — | US | disclosed |