Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 16/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 16/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14685160 | 0.80 | PDE10A (0.41) | PDE4AALOX5PDE4BPDE4DPDE4C | |
| SCHEMBL2749627 | 0.76 | PDE4B (0.35) | PDE4AALOX5PDE4BPDE4DPDE4C | |
| SCHEMBL22330398 | 0.76 | PDE4B (0.34) | PDE4AALOX5PDE4BPDE4DPDE4C | |
| SCHEMBL31165789 | 0.75 | PDE4A (0.48) | PDE4APDE4BPDE4DPDE4CMKNK1 | |
| SCHEMBL20771485 | 0.75 | PDE4B (0.39) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL3948108 | 0.74 | ALOX5 (0.36) | PDE4AALOX5PDE4BPDE4DPDE4C | |
| SCHEMBL17121438 | 0.72 | PDE4A (0.48) | PDE4APDE4BPDE4DPDE4CMKNK1 | |
| SCHEMBL1745964 | 0.72 | PDE4A (0.48) | PDE4APDE4BPDE4DPDE4CMKNK1 | |
| SCHEMBL4710416 | 0.71 | MAPKAPK2 (0.44) | PDE4APDE4BPDE4DPDE4CMKNK1 | |
| SCHEMBL20778287 | 0.71 | PDE4B (0.43) | PDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2740730-B1 | DIBENZOOXEPIN DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2016-11-16 | — | — | EP | disclosed |
| US-8969345-B2 | Dibenzooxepin derivative | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2015-03-03 | — | — | US | disclosed |
| US-20140163008-A1 | DIBENZOOXEPIN DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2014-06-12 | — | — | US | disclosed |
| EP-2740730-A1 | DIBENZOOXEPIN DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2014-06-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163008-A1 | DIBENZOOXEPIN DERIVATIVE | PPARA, PPARG, PPARD | PDE4A 1095/4885ALOX5 512/4885PDE4B 1267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.