Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 4/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15771661 | 1.00 | KDM4E (0.39) | KDM4EALDH1A1HPGDRCE1JAK2 | |
| SCHEMBL1966568 | 0.84 | NR1H2 (0.39) | KDM4EALDH1A1KMT2ACTSLGAA | |
| SCHEMBL13505420 | 0.83 | MAPT (0.44) | JAK2CTSSCTSKKMT2AATM | |
| SCHEMBL13505424 | 0.83 | MAPT (0.44) | JAK2CTSSCTSKKMT2AATM | |
| SCHEMBL15772515 | 0.82 | NPC1 (0.41) | KDM4EALDH1A1RCE1EPHX2KMT2A | |
| SCHEMBL15772516 | 0.82 | NPC1 (0.41) | KDM4EALDH1A1RCE1EPHX2KMT2A | |
| SCHEMBL15772589 | 0.81 | CTSS (0.37) | KDM4EJAK2CTSSCTSKKMT2A | |
| SCHEMBL11037391 | 0.81 | CNR2 (0.39) | KDM4EALDH1A1HPGDRCE1SUV39H2 | |
| SCHEMBL15772590 | 0.81 | CTSS (0.37) | KDM4EJAK2CTSSCTSKKMT2A | |
| SCHEMBL15771839 | 0.80 | NPC1 (0.45) | KDM4EALDH1A1RCE1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103649089-B | Pyrrolotriazinones as PI3K inhibitors | 阿尔米雷尔有限公司 | 2016-06-29 | — | — | CN | disclosed |
| US-9340547-B2 | Pyrrolotriazinone derivatives as inhibitors P13K | ALMIRALL, S.A. (ES) | 2016-05-17 | — | — | US | disclosed |
| EP-2702061-B9 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | ALMIRALL SA (ES) | 2016-02-24 | — | — | EP | disclosed |
| EP-2702061-B1 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | ALMIRALL SA (ES) | 2015-07-29 | — | — | EP | disclosed |
| US-20150099752-A9 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | ALMIRALL, SA (ES) | 2015-04-09 | — | — | US | disclosed |
| US-20140163033-A1 | PYRROLOTRIAZINONE DERIVATIVES AS P13K INHIBITORS | ALMIRALL, SA (ES) | 2014-06-12 | — | — | US | disclosed |
| CN-103649089-A | Pyrrolotriazinones as PI3K inhibitors | ALMIRALL SA | 2014-03-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163033-A1 | PYRROLOTRIAZINONE DERIVATIVES AS P13K INHIBITORS | PIP4K2B, PDPK1, PI4KA | KDM4E 1392/4885ALDH1A1 3142/4885HPGD 1914/4885 |
| US-20150099752-A9 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | PIK3CD, PIK3CA, PIK3CB | KDM4E 2489/4885ALDH1A1 3538/4885HPGD 1133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.