Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 18/20 | 1.00 |
| ▸ | TNKS2 | Q9H2K2 | 18/20 | 1.00 |
| ▸ | PARP1 | P09874 | 14/20 | 1.00 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.71 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.61 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7568904 | 0.88 | TNKS (1.00) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL1387200 | 0.87 | TNKS (1.00) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL167751 | 0.86 | TNKS (1.00) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL15775695 | 0.86 | TNKS (1.00) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL7568427 | 0.86 | TNKS (1.00) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL15775321 | 0.86 | TNKS (1.00) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL15775251 | 0.83 | TNKS (1.00) | TNKSTNKS2PARP1PARP2CYP1A1 | |
| SCHEMBL7569433 | 0.82 | TNKS (0.73) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL7568265 | 0.82 | TNKS (1.00) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL1387251 | 0.81 | TNKS (1.00) | TNKSTNKS2PARP1PARP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |