Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 18/20 | 1.00 |
| ▸ | TNKS2 | Q9H2K2 | 18/20 | 1.00 |
| ▸ | PARP1 | P09874 | 15/20 | 1.00 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.73 |
| ▸ | WNT3A | P56704 | 1/20 | 0.64 |
| ▸ | COMT | P21964 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL167751 | 0.85 | TNKS (1.00) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL7568904 | 0.85 | TNKS (1.00) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL15775279 | 0.84 | TNKS (1.00) | TNKSTNKS2PARP1PARP2WNT3A | |
| SCHEMBL1387200 | 0.83 | TNKS (1.00) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL7568427 | 0.82 | TNKS (1.00) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL15775321 | 0.82 | TNKS (1.00) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL15775695 | 0.82 | TNKS (1.00) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL15775244 | 0.82 | TNKS (1.00) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL7570390 | 0.81 | TNKS (1.00) | TNKSTNKS2PARP1PARP2WNT3A | |
| SCHEMBL15775430 | 0.79 | TNKS (0.65) | TNKSTNKS2PARP1PARP2WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966476-B1 | Quinazolinone compounds | UNIV NEWCASTLE VENTURES LTD (GB) | 2002-09-04 | — | — | EP | claimed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |
| EP-0966476-B1 | Quinazolinone compounds | UNIV NEWCASTLE VENTURES LTD (GB) | 2002-09-04 | — | — | EP | disclosed |
| EP-0966476-A1 | QUINAZOLINONE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998033802-A1 | QUINAZOLINONE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1998-08-06 | — | — | WO | disclosed |