Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.74 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.74 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | DHODH | Q02127 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL786246 | 0.88 | PDCD1 (0.81) | PDCD1CD274SIRT2NPC1RAB9A | |
| SCHEMBL23258276 | 0.87 | PDCD1 (0.74) | PDCD1CD274SIRT2NPC1RAB9A | |
| SCHEMBL21446872 | 0.85 | PDCD1 (1.00) | PDCD1CD274SIRT2NPC1RAB9A | |
| SCHEMBL14252955 | 0.85 | PDCD1 (0.72) | PDCD1CD274SIRT2NPC1RAB9A | |
| SCHEMBL11079536 | 0.85 | PDCD1 (0.72) | PDCD1CD274SIRT2NPC1RAB9A | |
| SCHEMBL11826793 | 0.85 | PDCD1 (0.72) | PDCD1CD274SIRT2NPC1RAB9A | |
| SCHEMBL5931215 | 0.85 | DHODH (0.76) | PDCD1CD274NPC1RAB9ADHODH | |
| SCHEMBL7103601 | 0.84 | MEN1 (0.68) | NPC1RAB9ADHODHMEN1KMT2A | |
| SCHEMBL15775396 | 0.83 | PTGS1 (0.68) | PDCD1CD274SIRT2NPC1RAB9A | |
| SCHEMBL7302098 | 0.83 | PDCD1 (0.68) | PDCD1CD274NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |