Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.68 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.68 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 8/20 | 0.64 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.55 |
| ▸ | PPARD | Q03181 | 2/20 | 0.55 |
| ▸ | PPARA | Q07869 | 2/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.55 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.55 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29085612 | 0.88 | RXFP1 (0.67) | PTGS1PDCD1CD274RXFP1NPC1 | |
| SCHEMBL4766874 | 0.86 | RXFP1 (0.73) | PTGS1RXFP1 | |
| SCHEMBL30932523 | 0.86 | RXFP1 (0.73) | PTGS1RXFP1 | |
| SCHEMBL7302098 | 0.85 | PDCD1 (0.68) | PDCD1CD274PPARGPPARANR1H4 | |
| SCHEMBL14252955 | 0.84 | PDCD1 (0.72) | PDCD1CD274SIRT2NPC1RAB9A | |
| SCHEMBL786246 | 0.84 | PDCD1 (0.81) | PDCD1CD274SIRT2NPC1RAB9A | |
| SCHEMBL23258276 | 0.83 | PDCD1 (0.74) | PDCD1CD274SIRT2NPC1RAB9A | |
| SCHEMBL15775304 | 0.83 | PDCD1 (0.74) | PDCD1CD274SIRT2KCNK2KCNK10 | |
| SCHEMBL28431283 | 0.82 | PTGS1 (0.61) | PTGS1RXFP1PPARGPPARDPPARA | |
| SCHEMBL21446872 | 0.81 | PDCD1 (1.00) | PDCD1CD274SIRT2PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |