Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 15/20 | 0.63 |
| ▸ | TNKS2 | Q9H2K2 | 15/20 | 0.63 |
| ▸ | PARP1 | P09874 | 11/20 | 0.63 |
| ▸ | MGAM | O43451 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SI | P14410 | 1/20 | 0.54 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.54 |
| ▸ | GUSB | P08236 | 1/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775324 | 0.88 | TNKS (0.61) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL15775475 | 0.87 | TNKS (0.60) | TNKSTNKS2PARP1GAAPARP2 | |
| SCHEMBL15775249 | 0.86 | TNKS (0.63) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL15775947 | 0.86 | TNKS (0.63) | TNKSTNKS2PARP1MGAMGAA | |
| SCHEMBL15775472 | 0.86 | TNKS (0.63) | TNKSTNKS2PARP1MGAMGAA | |
| SCHEMBL15775690 | 0.86 | TNKS (0.63) | TNKSTNKS2PARP1PARP2ADORA2B | |
| SCHEMBL15775567 | 0.85 | PARP1 (0.61) | TNKSTNKS2PARP1MGAMGAA | |
| SCHEMBL15775351 | 0.83 | TNKS (0.64) | TNKSTNKS2PARP1GUSBPARP2 | |
| Bromide SCHEMBL15775841 | 0.82 | TNKS (0.65) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL15775277 | 0.82 | TNKS (0.65) | TNKSTNKS2PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |