Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 11/20 | 0.60 |
| ▸ | TNKS2 | Q9H2K2 | 11/20 | 0.60 |
| ▸ | PARP1 | P09874 | 7/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | RPA1 | P27694 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775324 | 0.89 | TNKS (0.61) | TNKSTNKS2PARP1KDM4EPARP2 | |
| SCHEMBL15775472 | 0.87 | TNKS (0.63) | TNKSTNKS2PARP1KDM4EGAA | |
| SCHEMBL15775352 | 0.87 | TNKS (0.63) | TNKSTNKS2PARP1GAAPARP2 | |
| SCHEMBL15775690 | 0.87 | TNKS (0.63) | TNKSTNKS2PARP1KDM4ENPC1 | |
| SCHEMBL15775249 | 0.87 | TNKS (0.63) | TNKSTNKS2PARP1MAPTPARP2 | |
| SCHEMBL15775947 | 0.87 | TNKS (0.63) | TNKSTNKS2PARP1GAAPARP2 | |
| SCHEMBL15775351 | 0.84 | TNKS (0.64) | TNKSTNKS2PARP1KDM4ENPC1 | |
| Bromide SCHEMBL15775841 | 0.83 | TNKS (0.65) | TNKSTNKS2PARP1KDM4EPARP2 | |
| SCHEMBL15775277 | 0.83 | TNKS (0.65) | TNKSTNKS2PARP1RAB9APARP2 | |
| SCHEMBL15775528 | 0.82 | TNKS (0.66) | TNKSTNKS2PARP1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |