Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 4/20 | 0.51 |
| ▸ | PARP1 | P09874 | 7/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.50 |
| ▸ | TNKS | O95271 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | RPA1 | P27694 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL853264 | 0.84 | SERPINE1 (0.66) | SERPINE1PARP1TNKS2TNKSKDM4E | |
| SCHEMBL15775856 | 0.81 | SERPINE1 (0.65) | SERPINE1PARP1TNKS2TNKSKDM4E | |
| SCHEMBL29031824 | 0.79 | ESR1 (0.50) | SERPINE1PARP1TNKS2TNKSKDM4E | |
| SCHEMBL853536 | 0.76 | PARP1 (0.50) | SERPINE1PARP1TNKS2TNKS | |
| Hydrochloric Acid SCHEMBL854662 | 0.75 | PARP1 (0.49) | SERPINE1PARP1TNKS2TNKS | |
| SCHEMBL31014299 | 0.72 | PARP1 (0.67) | PARP1TNKS2TNKSKDM4EHPGD | |
| SCHEMBL15775395 | 0.72 | PARP1 (0.67) | PARP1TNKS2TNKSKDM4EHPGD | |
| SCHEMBL854581 | 0.68 | SERPINE1 (1.00) | SERPINE1PARP1TNKS2TNKSKDM4E | |
| SCHEMBL29031883 | 0.68 | SERPINE1 (0.67) | SERPINE1PARP1TNKS2TNKSKDM4E | |
| SCHEMBL29639174 | 0.68 | SERPINE1 (0.67) | SERPINE1PARP1TNKS2TNKSKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | claimed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |