Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 1.00 |
| ▸ | TNKS | O95271 | 2/20 | 1.00 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775183 | 0.86 | PARP1 (0.77) | PARP1TNKSTNKS2ALDH1A1KDM4E | |
| SCHEMBL15775736 | 0.86 | PARP1 (1.00) | PARP1TNKSTNKS2ALDH1A1MAPT | |
| SCHEMBL15775190 | 0.84 | PARP1 (0.73) | PARP1TNKSTNKS2ALDH1A1MAPT | |
| SCHEMBL15775243 | 0.83 | TNKS (0.72) | PARP1TNKSTNKS2ADORA2BADORA2A | |
| SCHEMBL18387671 | 0.70 | TNKS (0.54) | PARP1TNKSTNKS2 | |
| SCHEMBL9184240 | 0.68 | PARP1 (0.51) | PARP1TNKSTNKS2ALDH1A1MAPT | |
| Biphenyl SCHEMBL28062042 | 0.67 | BRD4 (0.68) | PARP1TNKSTNKS2ALDH1A1MAPT | |
| SCHEMBL2733549 | 0.66 | TNKS (0.49) | PARP1TNKSTNKS2ALDH1A1MAPT | |
| SCHEMBL1252512 | 0.66 | PARP1 (0.49) | PARP1TNKSTNKS2ALDH1A1KDM4E | |
| SCHEMBL2367416 | 0.66 | PARP1 (0.60) | PARP1TNKSTNKS2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |