Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.69 |
| ▸ | TNKS | O95271 | 10/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.48 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | GUSB | P08236 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775297 | 0.86 | PARP1 (0.67) | PARP1TNKSKDM4ETNKS2SERPINE1 | |
| SCHEMBL15775728 | 0.85 | TNKS (0.64) | PARP1TNKSKMT2ATNKS2MEN1 | |
| SCHEMBL15567668 | 0.85 | PARP1 (0.69) | PARP1TNKSKDM4EKMT2ATNKS2 | |
| SCHEMBL15775421 | 0.82 | TNKS (0.73) | PARP1TNKSTNKS2PARP2 | |
| SCHEMBL15776266 | 0.82 | PARP1 (0.69) | PARP1TNKSKDM4EKMT2APDE10A | |
| SCHEMBL15791061 | 0.82 | PARP1 (1.00) | PARP1TNKSKDM4EKMT2APDE10A | |
| SCHEMBL15775754 | 0.81 | PARP1 (0.71) | PARP1TNKSKDM4EKMT2ATNKS2 | |
| Hydrochloric Acid SCHEMBL15775429 | 0.81 | PARP1 (0.97) | PARP1TNKSKDM4EKMT2APDE10A | |
| SCHEMBL15569103 | 0.79 | TNKS (0.60) | PARP1TNKSTNKS2PARP2 | |
| SCHEMBL15776281 | 0.78 | TNKS (0.78) | PARP1TNKSKDM4EKMT2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | claimed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |