Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.71 |
| ▸ | TNKS | O95271 | 7/20 | 0.65 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.50 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766919 | 0.84 | PARP1 (0.73) | PARP1TNKSTNKS2ALDH1A1KDM4E | |
| SCHEMBL15567668 | 0.84 | PARP1 (0.69) | PARP1TNKSTNKS2KDM4EHPGD | |
| SCHEMBL15775405 | 0.83 | PARP1 (1.00) | PARP1TNKSTNKS2ALDH1A1KDM4E | |
| SCHEMBL15775297 | 0.82 | PARP1 (0.67) | PARP1TNKSTNKS2ALDH1A1KDM4E | |
| SCHEMBL15775477 | 0.81 | PARP1 (0.69) | PARP1TNKSTNKS2ALDH1A1KDM4E | |
| SCHEMBL15775728 | 0.81 | TNKS (0.64) | PARP1TNKSTNKS2MEN1KMT2A | |
| SCHEMBL16578778 | 0.81 | PARP1 (0.68) | PARP1TNKSTNKS2ALDH1A1KDM4E | |
| SCHEMBL16625190 | 0.80 | TNKS (0.78) | PARP1TNKSTNKS2GSK3B | |
| SCHEMBL15775317 | 0.79 | PARP1 (0.65) | PARP1TNKSTNKS2ALDH1A1KDM4E | |
| SCHEMBL15775421 | 0.79 | TNKS (0.73) | PARP1TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | claimed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |