Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 14/20 | 1.00 |
| ▸ | TNKS | O95271 | 4/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15791062 | 0.87 | PARP1 (0.77) | PARP1TNKSTNKS2CTSVCTSL | |
| Bromide SCHEMBL15775305 | 0.86 | PARP1 (0.74) | PARP1TNKS | |
| SCHEMBL15775367 | 0.86 | PARP1 (1.00) | PARP1TNKSTNKS2CTSVCTSL | |
| SCHEMBL15791061 | 0.86 | PARP1 (1.00) | PARP1TNKSTNKS2KDM4E | |
| Bromide SCHEMBL15775831 | 0.86 | PARP1 (0.75) | PARP1TNKSTNKS2CTSVCTSL | |
| Hydrochloric Acid SCHEMBL15775429 | 0.84 | PARP1 (0.97) | PARP1TNKSTNKS2KDM4E | |
| Bromide SCHEMBL15775373 | 0.84 | PARP1 (0.73) | PARP1TNKSTNKS2 | |
| Bromide SCHEMBL15775611 | 0.83 | PARP1 (0.74) | PARP1TNKSKDM4ELMNAHPGD | |
| SCHEMBL15775405 | 0.82 | PARP1 (1.00) | PARP1TNKSTNKS2KDM4ELMNA | |
| SCHEMBL15775979 | 0.82 | PARP1 (0.69) | PARP1TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |