Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2425205 | 0.83 | PIM1 (0.38) | PIM1PIM3PIM2ATMKDM4E | |
| SCHEMBL2425207 | 0.83 | PIM1 (0.38) | PIM1PIM3PIM2ATMKDM4E | |
| SCHEMBL28232720 | 0.74 | PIM1 (0.41) | PIM1PIM3PIM2ATMKDM4E | |
| SCHEMBL12283721 | 0.72 | MAP4K4 (0.49) | PIM1PIM3PIM2DPP4L3MBTL1 | |
| SCHEMBL2425209 | 0.72 | MAP4K4 (0.49) | PIM1PIM3PIM2DPP4L3MBTL1 | |
| SCHEMBL15880147 | 0.69 | MEN1 (0.45) | PIM2ALDH1A1KMT2AMEN1 | |
| SCHEMBL15880144 | 0.69 | MEN1 (0.45) | PIM2ALDH1A1KMT2AMEN1 | |
| SCHEMBL28777662 | 0.69 | HRH3 (0.34) | CYP3A4 | |
| SCHEMBL28777659 | 0.69 | HRH3 (0.34) | CYP3A4 | |
| SCHEMBL28544416 | 0.69 | DGAT2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310010-A2 | CHEMICAL COMPOUNDS 251 | AstraZeneca AB (SE) | 2011-04-20 | — | — | EP | disclosed |
| WO-2010001169-A2 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | WO | disclosed |