Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 3/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15799618 | 1.00 | EPHX2 (0.45) | EPHX2GAADRD2NAAASIRT2 | |
| SCHEMBL15811245 | 0.84 | EPHX2 (0.51) | EPHX2GAANAAARIPK1 | |
| SCHEMBL15964542 | 0.82 | RIPK1 (0.53) | EPHX2GAADRD2SIRT2SIRT1 | |
| SCHEMBL645858 | 0.82 | EPHX2 (0.62) | EPHX2GAANAAARIPK1 | |
| SCHEMBL949512 | 0.82 | EPHX2 (0.62) | EPHX2GAANAAARIPK1 | |
| SCHEMBL3485516 | 0.82 | EPHX2 (0.62) | EPHX2GAANAAARIPK1 | |
| SCHEMBL29796852 | 0.81 | GAA (0.40) | EPHX2GAADRD2SIRT2SIRT1 | |
| SCHEMBL26961667 | 0.81 | GAA (0.40) | EPHX2GAADRD2SIRT2SIRT1 | |
| SCHEMBL6176701 | 0.80 | EPHX2 (0.51) | EPHX2GAANAAARIPK1 | |
| SCHEMBL4988872 | 0.80 | EPHX2 (0.47) | EPHX2GAANAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931719-B1 | DIMERIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2017-01-25 | — | — | EP | disclosed |
| EP-2931719-B1 | DIMERIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2017-01-25 | — | — | EP | disclosed |
| US-9409888-B2 | Dimeric compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-08-09 | — | — | US | disclosed |
| US-9409888-B2 | Dimeric compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-08-09 | — | — | US | disclosed |
| US-9409888-B2 | Dimeric compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-08-09 | — | — | US | disclosed |
| US-20160024055-A1 | DIMERIC COMPOUNDS | HOFFMANN-LA ROCHE INC. | 2016-01-28 | — | — | US | disclosed |
| US-20160024055-A1 | DIMERIC COMPOUNDS | HOFFMANN-LA ROCHE INC. | 2016-01-28 | — | — | US | disclosed |
| US-20160024055-A1 | DIMERIC COMPOUNDS | HOFFMANN-LA ROCHE INC. | 2016-01-28 | — | — | US | disclosed |
| EP-2931719-A1 | DIMERIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2015-10-21 | — | — | EP | disclosed |
| WO-2014090709-A1 | DIMERIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024055-A1 | DIMERIC COMPOUNDS | ZYX, TP53, ZFX | EPHX2 1294/4885GAA 1093/4885DRD2 2238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.